Acute Manganese Nitrate Toxicity: It can lead to more severe symptoms, including tremors, muscle spasms, and changes in behavior. In extreme cases, it can cause coma and death.

Chronic Manganese Nitrate Toxicity: Even at lower levels, it can also have adverse health effects. Prolonged exposure to manganese nitrate has been linked to neurotoxic effects, including changes in behavior, mood, and cognition.

These adverse health effects, particularly the neurologic ones, may follow a "continuum of dysfunction" dose-related. In other words, modest but physiologically excessive levels of manganese may induce mild or undetectable impacts, and these effects worsen with exposure level or exposure duration.